Induced hypothermia to treat post - ischemic and post - traumatic injury
نویسنده
چکیده
Scand J Trauma Res Emerg Med 2003; 12(1):
منابع مشابه
اثر متیل پردنیزولون بر ضربالعجل درمانی هیپوترمی سیستمیک در درمان ضایعه تروماتیک تجربی خفیف نخاع در رت
Background and Aim: Many studies have shown the neuroprotective effect of systemic hypothermia in the treatment of spinal cord injury. But the effect of delay hypothermia is not known.The goal of this study was to evaluate the effects of Methylprednisolone on the therapeutic window of hypothermia treatment following experimental Spinal Cord Injury (SCI) by measuring the accumulation of Poly...
متن کاملPost-ischemic diazepam does not reduce hippocampal CA1 injury and does not improve hypothermic neuroprotection after forebrain ischemia in gerbils.
The hippocampal CA1 sector is especially vulnerable to brief forebrain ischemia. Excitotoxicity is widely thought to contribute to this cell death. Accordingly, drugs that presumably counteract excitotoxicity, such as GABAergic agonists, have been repeatedly tested and found to reduce CA1 cell loss. Post-ischemic diazepam reduces CA1 injury. However, diazepam also causes hypothermia, which by i...
متن کاملTherapeutic hypothermia for acute brain injuries
Therapeutic hypothermia, recently termed target temperature management (TTM), is the cornerstone of neuroprotective strategy. Dating to the pioneer works of Fay, nearly 75 years of basic and clinical evidence support its therapeutic value. Although hypothermia decreases the metabolic rate to restore the supply and demand of O₂, it has other tissue-specific effects, such as decreasing excitotoxi...
متن کاملMild hypothermia reduces cardiac post-ischemic reactive hyperemia
BACKGROUND In experimentally induced myocardial infarction, mild hypothermia (33-35 degrees C) is beneficial if applied prior to ischemia or reperfusion. Hypothermia, when applied after reperfusion seems to confer little or no benefit. The mechanism by which hypothermia exerts its cell-protective effect during cardiac ischemia remains unclear. It has been hypothesized that hypothermia reduces t...
متن کاملTherapeutic Hypothermia
Therapeutic hypothermia has been advocated for neuroprotection in cardiac arrest-induced encephalopathy, neonatal hypoxic-ischemic encephalopathy, traumatic brain injury, stroke, hepatic encephalopathy, and spinal cord injury, and as an adjunct to certain surgical procedures. In this review, we address physiological mechanism of hypothermia to mitigate neurological injury, the trials that have ...
متن کامل